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Computational Structural Proteomics Lars Brive and Ruben Abagyan

Summary: Computational Structural Proteomics
Lars Brive and Ruben Abagyan
Department of Molecular Biology, The Scripps Research Institute, 10550
North Torrey Pines Road, La Jolla, CA 92037, USA
1 Introduction
1.1 New sequences from proteomics and genomics
Genomics and proteomics efforts generate new results at a remarkable pace. Over 30
organisms have been sequenced and contribute evolutionary information and new
proteins with yet unknown function that are important from a basic research point of view
and for biomedical research. We now need ways to analyze the information and make
something useful of it, which may turn out to be a major obstacle. From a protein
structure point of view, the DNA sequences have to be analyzed for coding regions,
protein constructs shall be expressed correctly at good yields, functions and properties
shall be determined, and the structure needs to be solved. For example, of the more than
600 predicted G-protein coupled receptors (GPCRs) in the human genome, 250-300 have
been annotated in swissprot, 100 have been experimentally characterized and only 2
crystal structures have been reported.
1.2 Structural proteomics
A complete understanding of protein function requires the structures of the individual
components and their complexes to be determined. The huge amount of data from


Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego


Collections: Biology and Medicine