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Temporal Dynamics of Convergent Modulation at a Crustacean Neuromuscular Junction
 

Summary: Temporal Dynamics of Convergent Modulation at a Crustacean
Neuromuscular Junction
JUAN CARLOS JORGE-RIVERA, KAMAL SEN, J. T. BIRMINGHAM, L. F. ABBOTT, AND EVE MARDER
Volen Center and Biology Department, Brandeis University, Waltham, Massachusetts 02454
Jorge-Rivera, Juan Carlos, Kamal Sen, J. T. Birmingham, L. F. (LP) neuron of the STG responds to almost all of these
Abbott, and Eve Marder. Temporal dynamics of convergent mod- (Flamm and Harris-Warrick 1986b; Hooper and Marder
ulation at a crustacean neuromuscular junction. J. Neurophysiol. 1987; Nusbaum and Marder 1988; Swensen and Marder
80: 25592570, 1998. At least 10 different substances modulate 1997; Weimann et al. 1993, 1997).
the amplitude of nerve-evoked contractions of the gastric mill 4
The neuromuscular preparations studied here include 2 of(gm4) muscle of the crab, Cancer borealis. Serotonin, dopamine,
the 40 striated muscles that are innervated by motor neu-octopamine, proctolin, red pigment concentrating hormone, crusta-
rons of the STG (Maynard and Dando 1974). Several previ-cean cardioactive peptide, TNRNFLRFamide, and SDRNFLRFam-
ous studies demonstrated neuromodulation of stomach mus-ide increased and D-allatostatin-3 and histamine decreased the
cles and neuromuscular junctions by an amine or peptideamplitude of nerve-evoked contractions. Modulator efficacy was
frequency dependent; TNRNFLRFamide, proctolin, and D- (Jorge-Rivera 1997; Jorge-Rivera and Marder 1996, 1997;
allatostatin-3 were more effective when the motor neuron was Lingle 1981; Meyrand and Marder 1991; Meyrand and Mou-
stimulated at 10 Hz than at 40 Hz, whereas the reverse was true lins 1986; Weimann et al. 1997), but this is the first study
for dopamine and serotonin. The modulators that were most effec- in which the actions of numerous potential neuromodulators
tive at high stimulus frequencies produced a significant decrease were studied on the same stomach neuromuscular junction.
in muscle relaxation time; those that were most effective at low

  

Source: Abbott, Laurence - Center for Neurobiology and Behavior & Department of Physiology and Cellular Biophysics, Columbia University

 

Collections: Biology and Medicine