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Visually Induced Adaptation in Three-Dimensional Organization of Primate Vestibuloocular Reflex

Summary: Visually Induced Adaptation in Three-Dimensional Organization of
Primate Vestibuloocular Reflex
Department of Surgery (Otolaryngology), University of Mississippi Medical Center, Jackson, Mississippi; and
Department of Neurology, University Hospital Zu¨rich, CH-8091 Zurich, Switzerland
Angelaki, Dora E. and Bernhard J. M. Hess. Visually induced stabilizes visual images on the retina. An important charac-
adaptation in three-dimensional organization of primate vestibulo- teristic of the VOR is that it operates in an ``open loop''
ocular reflex. J. Neurophysiol. 79: 791­807, 1998. The adaptive fashion, i.e., the elicited eye movements are not sensed by
plasticity of the spatial organization of the vestibuloocular reflex
the labyrinthine receptors that generate them. Therefore,
(VOR) has been investigated in intact and canal-plugged primates
there must exist other mechanisms that control and adjustusing 2-h exposure to conflicting visual (optokinetic, OKN) and
VOR gain to optimize gaze stabilization. Errors in VORvestibular rotational stimuli about mutually orthogonal axes (gen-
calibration result in retinal image slip, which activates adap-erating torsional VOR / vertical OKN, torsional VOR / horizontal
tive mechanisms to modify central VOR circuits.OKN, vertical VOR / horizontal OKN, and horizontal VOR /
vertical OKN). Adaptation protocols with 0.5-Hz ({18 ) head Adaptation of VOR response gain has been demonstrated
movements about either an earth-vertical or an earth-horizontal in several species including man (Berthoz et al. 1981; Demer
axis induced orthogonal response components as high as 40­70% et al. 1989; Gauthier and Robinson 1975; Gonshor and
of those required for ideal adaptation. Orthogonal response gains Melvill Jones 1976a,b; Paige and Sargent 1991), monkeys
were highest at the adapting frequency with phase leads present at


Source: Angelaki, Dora - Department of Anatomy and Neurobiology, Washington University in St. Louis


Collections: Biology and Medicine