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Fine-mapping alleles for body weight in LG/J 3 SM/J F2 and F34 advanced intercross lines
 

Summary: Fine-mapping alleles for body weight in LG/J 3 SM/J F2 and F34
advanced intercross lines
Clarissa C. Parker Riyan Cheng Greta Sokoloff
Jackie E. Lim Andrew D. Skol Mark Abney
Abraham A. Palmer
Received: 28 February 2011 / Accepted: 21 June 2011 / Published online: 15 July 2011
Springer Science+Business Media, LLC 2011
Abstract The present study measured variation in body
weight using a combined analysis in an F2 intercross and an
F34 advanced intercross line (AIL). Both crosses were
derived from inbred LG/J and SM/J mice, which were
selected for large and small body size prior to inbreeding.
Body weight was measured at 62 (5) days of age. Using
an integrated GWAS and forward model selection
approach, we identified 11 significant QTLs that affected
body weight on ten different chromosomes. With these
results we developed a full model that explained over 18%
of the phenotypic variance. The median 1.5-LOD support
interval was 5.55 Mb, which is a significant improvement
over most prior body weight QTLs. We identified

  

Source: Abney, Mark - Department of Human Genetics, University of Chicago

 

Collections: Computer Technologies and Information Sciences; Biology and Medicine