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Summary: Fine-mapping alleles for body weight in LG/J 3 SM/J F2 and F34
advanced intercross lines
Clarissa C. Parker · Riyan Cheng · Greta Sokoloff ·
Jackie E. Lim · Andrew D. Skol · Mark Abney ·
Abraham A. Palmer
Received: 28 February 2011 / Accepted: 21 June 2011 / Published online: 15 July 2011
Ó Springer Science+Business Media, LLC 2011
Abstract The present study measured variation in body
weight using a combined analysis in an F2 intercross and an
F34 advanced intercross line (AIL). Both crosses were
derived from inbred LG/J and SM/J mice, which were
selected for large and small body size prior to inbreeding.
Body weight was measured at 62 (±5) days of age. Using
an integrated GWAS and forward model selection
approach, we identified 11 significant QTLs that affected
body weight on ten different chromosomes. With these
results we developed a full model that explained over 18%
of the phenotypic variance. The median 1.5-LOD support
interval was 5.55 Mb, which is a significant improvement
over most prior body weight QTLs. We identified
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