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Cell, Vol. 103, 10991109, December 22, 2000, Copyright 2000 by Cell Press Dedifferentiation of Mammalian Myotubes

Summary: Cell, Vol. 103, 1099­1109, December 22, 2000, Copyright ©2000 by Cell Press
Dedifferentiation of Mammalian Myotubes
Induced by msx1
the terminal differentiation pathway and begin to ex-
press, in succession, a number of muscle differentiation
factors. These include myogenin, the cdk inhibitor p21/
Shannon J. Odelberg,*§ Angela Kollhoff,
and Mark T. Keating* #
*Division of Cardiology, Department of Internal
Medicine WAF1, activated retinoblastoma protein, and the muscle
contractile proteins (e.g., myosin heavy chain and tropo- Howard Hughes Medical Institute
Department of Human Genetics nin T). The differentiating cells align along their axes and
fuse to form terminally differentiated myotubes capable§ Department of Pediatrics
University of Utah of muscle contraction.
This differentiation process is thought to be irrevers-Salt Lake City, Utah 84112
ible in mammalian myotubes. By contrast, urodele am-
phibians show a remarkable plasticity in cellular differ-
entiation. Urodeles are capable of regenerating severalSummary
anatomical structures, including limbs, tail, eye lenses,
retinas, upper and lower jaws, dorsal crest, spinal cord,The process of cellular differentiation culminating in


Source: Alvarado, Alejandro Sánchez - Department of Neurobiology and Anatomy, University of Utah


Collections: Biology and Medicine