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The Journal of Neuroscience, December 1991, f f(12): 39303939 Opiate Withdrawal-induced Hyperactivity of Locus Coeruleus
 

Summary: The Journal of Neuroscience, December 1991, f f(12): 39303939
Opiate Withdrawal-induced Hyperactivity of Locus Coeruleus
Neurons Is Substantially Mediated by Augmented Excitatory
Amino Acid Input
Hideo Akaoka and Gary Aston-Jones
Department of Mental Health Sciences, Division of Behavioral Neurobiology, Hahnemann University, Philadelphia,
Pennsylvania 19102
Single-cell activity was recorded in the locus coeruleus (LC)
of morphine-dependent, halothane-anesthetized rats. Sys-
temic administration of the opiate antagonist naloxone (0.1
mg/kg, i.v.) robustly increased the activity of LC neurons.
Local microinjection of naloxone or of its hydrophilic deriv-
ative, naloxone methiodide, into LC (10 mh!, 20-40 nl) did
not activate LC neurons in dependent rats. Intracerebroven-
tricular or intracoerulear injection of kynurenate, a broad-
spectrum antagonist of excitatory amino acids (EAAs), sub-
stantially but incompletely attenuated the activation of LC
cells induced by intravenous naloxone-precipitated with-
drawal (more than 50% blockade). lntracoerulear microin-
jections of the non-NMDA-receptor antagonist 6-cyano-7-

  

Source: Aston-Jones, Gary - Department of Neurosciences, Medical University of South Carolina

 

Collections: Biology and Medicine