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Cell, Vol. 66, 257-270, July 26, 1991, Copyright 0 1991 by Cell Press Expression of a Dominant Negative Mutant of the
 

Summary: Cell, Vol. 66, 257-270, July 26, 1991, Copyright 0 1991 by Cell Press
Expression of a Dominant Negative Mutant of the
FGF Receptor Disrupts Mesoderm Formation
in Xenopk Embryos
Enrique Amaya,' Thomas J. Musci,"t
and Marc W. Kirschner*
*Department of Biochemistry and Biophysics
tDepartment of Obstetrics, Gynecology
and Reproductive Sciences
University of California
San Francisco, California 94143
Peptide growth factors may play a role in patterning
of the early embryo, particularly in the induction of
mesoderm. We have explored the role of fibroblast
growth factor (FGF) in early Xenopus development by
expressing a dominant negative mutant form of the
FGF receptor. Using a functional assay in frog oocytes,
we found that a truncated form of the receptor effec-
tively abolished wild-type receptor function. Explants
from embryos expressing this dominant negative mu-

  

Source: Amaya, Enrique - Healing Foundation Centre & Developmental Biology, Faculty of Life Sciences, University of Manchester

 

Collections: Biology and Medicine