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Sugar Nucleotide Regeneration Beads (Superbeads): A Versatile Tool for the Practical Synthesis of
 

Summary: Sugar Nucleotide Regeneration Beads (Superbeads):
A Versatile Tool for the Practical Synthesis of
Oligosaccharides
Xi Chen, Jianwen Fang, Jianbo Zhang, Ziye Liu, Jun Shao,
Przemyslaw Kowal, Peter Andreana, and Peng George Wang*
Department of Chemistry, Wayne State UniVersity
Detroit, Michigan 48202
ReceiVed October 27, 2000
Application of carbohydrates in modern medicine is limited by
the high cost of synthesis of most biologically important glyco-
conjugates. It is generally recognized that glycosyltransferase-
catalyzed glycosylation is one of the most practical approaches.1
Glycosyltransferases catalyze the transfer of a specific sugar from
its sugar-nucleotide donor to an acceptor with high regio- and
stereoselectivity. With increasing availability of recombinant
glycosyltransferases in recent years, it can be expected that more
researchers will use these enzymes to construct different glyco-
conjugates. The roadblock for practical use of this methodology
is the high cost of necessary sugar nucleotides. So far the best
solution is either using multiple-microbial fermentation systems

  

Source: Andreana, Peter R. - Department of Chemistry, Wayne State University
Chen, Xi - Department of Chemistry, University of California, Davis

 

Collections: Chemistry