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Genome-wide scan reveals association of psoriasis with IL-23 and NF-kB pathways

Summary: Genome-wide scan reveals association of psoriasis with
IL-23 and NF-kB pathways
Rajan P Nair1,19, Kristina Callis Duffin2,19, Cynthia Helms3,19, Jun Ding4,19, Philip E Stuart1, David Goldgar2,
Johann E Gudjonsson1, Yun Li4, Trilokraj Tejasvi1, Bing-Jian Feng2, Andreas Ruether5, Stefan Schreiber5,
Michael Weichenthal6, Dafna Gladman7, Proton Rahman8, Steven J Schrodi9, Sampath Prahalad10­12,
Stephen L Guthery10­12, Judith Fischer13, Wilson Liao14, Pui-Yan Kwok14, Alan Menter15, G Mark Lathrop13,
Carol A Wise16, Ann B Begovich9, John J Voorhees1, James T Elder1,17,20, Gerald G Krueger2,20,
Anne M Bowcock3,20 & Gonc¸alo R Abecasis4,20, for the Collaborative Association Study of Psoriasis18
Psoriasis is a common immune-mediated disorder that affects
the skin, nails and joints. To identify psoriasis susceptibility
loci, we genotyped 438,670 SNPs in 1,409 psoriasis cases
and 1,436 controls of European ancestry. We followed up 21
promising SNPs in 5,048 psoriasis cases and 5,041 controls.
Our results provide strong support for the association of at
least seven genetic loci and psoriasis (each with combined
P o 5 Â 10À8). Loci with confirmed association include
HLA-C, three genes involved in IL-23 signaling (IL23A, IL23R,
IL12B), two genes that act downstream of TNF-a and regulate
NF-jB signaling (TNIP1, TNFAIP3) and two genes involved in
the modulation of Th2 immune responses (IL4, IL13). Although


Source: Abecasis, Goncalo - Department of Biostatistics, University of Michigan


Collections: Biology and Medicine; Mathematics