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Neuron, Vol. 20, 10511057, June, 1998, Copyright 1998 by Cell Press fMRI of Monkey Visual Cortex Neurotechnique

Summary: Neuron, Vol. 20, 1051­1057, June, 1998, Copyright ©1998 by Cell Press
fMRI of Monkey Visual Cortex Neurotechnique
rapidly identifying brain regions involved in perception,Lisa Stefanacci,*# Paul Reber,* Jennifer Costanza,
Eric Wong,* Richard Buxton, Stuart Zola,*§ cognition, and motor function and as a complement to
traditional experimental approaches such as single-cellLarry Squire,*§ and Thomas Albright
*Department of Psychiatry electrophysiology, neuroanatomical tract tracing, and
studies of the behavioral effects of focal brain lesions.University of California
La Jolla, California 92093 Moreover, in combination with microelectrode record-
ing, the application of fMRI in monkeys holds promiseHoward Hughes Medical Institute
Salk Institute for Biological Studies for clarifying the relationship between neuronal activity
and the BOLD (blood oxygenation level­dependent) sig-La Jolla, California 92037
Department of Radiology nal of fMRI.
There are a number of significant technical challengesUniversity of California
San Diego, California 92103 involved in carrying out fMRI experiments in monkeys,
arising from the need to use alert (unanesthetized) mon-§Department of Neurosciences
University of California keys for the experiment. While apparatus and proce-
dures for behavioral control of alert monkeys, and forLa Jolla, California 92093
Veterans Administration Medical Center their immobilization in a confined space, have been well
developed for single-cell electrophysiological experi-San Diego, California 92161
ments and can be adapted for use in fMRI, there are


Source: Albright, Tom - Vision Center Laboratory, Salk Institute for Biological Studies


Collections: Biology and Medicine