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Summary: LETTERS
IgH class switching and translocations use a robust
non-classical end-joining pathway
Catherine T. Yan1,2,3,4
, Cristian Boboila1,2,3,4
, Ellen Kris Souza1,2,3,4
, Sonia Franco1,2,3,4
, Thomas R. Hickernell1,2,3,4
,
Michael Murphy1,2,3,4
, Sunil Gumaste1,2,3,4
, Mark Geyer2
, Ali A. Zarrin1,2,3,4
, John P. Manis2,5
, Klaus Rajewsky3,5
& Frederick W. Alt1,2,3,4
Immunoglobulin variable region exons are assembled in deve-
loping B cells by V(D)J recombination. Once mature, these cells
undergo class-switch recombination (CSR) when activated by
antigen. CSR changes the heavy chain constant region exons
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