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Biochemistry Insect Biochemistry and Molecular Biology 36 (2006) 921933

Summary: Insect
Insect Biochemistry and Molecular Biology 36 (2006) 921≠933
Molecular characterization of iron binding proteins from Glossina
morsitans morsitans (Diptera: Glossinidae)
Patricia M. Strickler-Dinglasan1
, Nurper Guz, Geoffrey Attardo, Serap Aksoy√
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06510, USA
Received 6 June 2006; received in revised form 7 September 2006; accepted 8 September 2006
The regulation of iron is critical for maintaining homeostasis in the tsetse fly (Diptera: Glossinidae), in which both adult sexes are strict
blood feeders. We have characterized the cDNAs for two putative iron-binding proteins (IBPs) involved in transport and storage;
transferrin (GmmTsf1) and ferritin from Glossina morsitans morsitans. GmmTsf1 transcripts are detected in the female fat body and in
adult reproductive tissues, and only in the adult developmental stage in a bloodmeal independent manner. In contrast, the ferritin heavy
chain (GmmFer1HCH) and light chain (GmmFer2LCH) transcripts are expressed ubiquitously, suggesting a more general role for these
proteins in iron transport and storage. Protein domain predictions for each IBP suggest both the conservation and loss of several motifs
present in their vertebrate homologues. In concert with many other described insect transferrins (Tfs), putative secreted GmmTsf1


Source: Aksoy, Serap - School of Public Health, Yale University


Collections: Biology and Medicine