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ELSEVIER Journal of Molecular Catalysis B: Enzymatic 2 (I 997) L253-L255 B: ENZYMATIC
 

Summary: ELSEVIER Journal of Molecular Catalysis B: Enzymatic 2 (I 997) L253-L255
JOURNAL OF
MOLECULAR
CATALYSIS
B: ENZYMATIC
Letter
Preparation of substituted ( R) -2-alkanols by microbial
hydroxylation
Herbert L. Holland *, Andreas Kohl, Brett G. Larsen, Peter Andreana, Jian-Xin Gu
Departmenf of Chernistn. Brock University, St. Cutharines, Ontario L2.S 3Al. Canada
Accepted 3 January 1997
Abstract
Hydroxylation of alkanenitriles (C, to C ,,,) and of 2-octanone, 2-nonanone and 2-decanone by Helminthosporiumspecies
NRRL 467 1 occurs predominantly at the ( OPI) position to give the corresponding ( R)-2-alkanols in > 95% enantiomeric
purity.
Keywords: Carbinol; Hydroxylation; Helminthosporium; NRRL 467 I
Microbial hydroxylation of a prochiral meth-
ylene group to generate a chiral alcohol is a
potentially powerful tool in synthetic organic
chemistry, but its practical application has been

  

Source: Andreana, Peter R. - Department of Chemistry, Wayne State University

 

Collections: Chemistry