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Contribution of cerebellar sensorimotor adaptation to hippocampal spatial memory

Summary: Contribution of cerebellar sensorimotor adaptation to
hippocampal spatial memory
Jean-Baptiste Passot, Denis Sheynikhovich, Eleonore Duvelle, Angelo Arleo
CNRS ­ UPMC Univ Paris 6, UMR 7102, F75005, Paris, France
Complementing its primary role in motor control, cerebellar learning has also a bottom-up
influence on cognitive functions, where high-level representations build up from elementary
sensorimotor memories. In this paper we examine the cerebellar contribution to both proce-
dural and declarative components of spatial cognition. To do so, we model a functional inter-
play between the cerebellum and the hippocampal formation during goal-oriented navigation.
We reinterpret and complete existing genetic behavioural observations by means of quantita-
tive accounts that cross-link synaptic plasticity mechanisms, single cell and population coding
properties, and behavioural responses. In contrast to earlier hypotheses positing only a purely
procedural impact of cerebellar adaptation deficits, our results suggest a cerebellar involvement
in high-level aspects of behaviour. In particular, we propose that cerebellar learning mecha-
nisms may influence hippocampal place fields, by contributing to the path integration process.

Corresponding author, email: angelo.arleo@upmc.fr, phone: +33 (0)1, fax: +33 (0)1
Our simulations predict differences in place-cell discharge properties between normal mice


Source: Arleo, Angelo - Laboratory of Neurobiology of Adaptive Processes, Université Pierre-et-Marie-Curie, Paris 6


Collections: Biology and Medicine