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Summary: Uremia Accelerates both Atherosclerosis and Arterial
Calcification in Apolipoprotein E Knockout Mice
Ziad A. Massy,*§
Ognen Ivanovski,* Thao Nguyen-Khoa,*
Jesus Angulo,
Dorota Szumilak,* Nadya Mothu,* Olivier Phan,* Michel Daudon,
Bernard Lacour,
Tilman B. Dru¨eke,* and Martin S. Muntzel
*INSERM Unit 507 and
Laboratory of Biochemistry A, Necker Hospital, Paris, and
Centre de Morphologie
Mathe´matique, Ecole des Mines, Fontainebleau, France; and §
Divisions of Clinical Pharmacology and Nephrology,
University of Picardie and Amiens University Hospital, Amiens; and Department of Biological Sciences, Lehman
College, Bronx, New York
Chronic renal failure (CRF) favors the development of atherosclerosis and excessive calcification of atheromatous lesions. CRF
was induced in apolipoprotein E knockout (apoE /
) mice to study (1) a possible acceleration of aortic atherosclerosis, (2) the
degree and type of vascular calcification, and (3) factors involved in the calcification process. For creating CRF, 8-wk-old
apolipoprotein E gene knockout (apoE /
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