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Research Roundup JCB VOLUME 171 NUMBER 1 200510

Summary: Research Roundup
JCB VOLUME 171 NUMBER 1 200510
Highly goes slowly
ates of protein evolution vary widely.
Very little of this variation is explained
by dispensability (essential proteins
evolving slowly), but up to a third is explained
by expression levels. For an entirely mysterious
reason, highly expressed proteins evolve slowly.
Now, Allan Drummond and colleagues
(Caltech, Pasadena, CA; and Keck Graduate
Institute, Claremont, CA) argue that this corre-
lation is based on the severe selective pres-
sure on highly expressed proteins to avoid
misfolding even when they are mistranslated.
More abundant proteins are a greater mis-
folding threat because even a low misfolding
rate would result in many misfolded, poten-
Pressure not to misfold means that higher


Source: Arnold, Frances H. - Division of Chemistry and Chemical Engineering, California Institute of Technology


Collections: Chemistry; Biology and Medicine