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The dynamic clamp comes of age Astrid A. Prinz, L.F. Abbott and Eve Marder

Summary: The dynamic clamp comes of age
Astrid A. Prinz, L.F. Abbott and Eve Marder
Volen Center and Department of Biology, Brandeis University, Waltham, MA 02454-9110, USA
The dynamic clamp uses computer simulation to intro-
duce artificial membrane or synaptic conductances into
biological neurons and to create hybrid circuits of real
and model neurons. In the ten years since it was first
developed, the dynamic clamp has become a widely
used tool for the study of neural systems at the cellular
and circuit levels. This review describes recent state-of-
the-art implementations of the dynamic clamp and
summarizes insights gained through its use, ranging
from the role of voltage-dependent conductances in
shaping neuronal activity to the effects of synaptic
dynamics on network behavior and the impact of
in vivo-like input on neuronal information processing.
The term dynamic clamp refers to a variety of hardware
and software implementations used to create artificial
conductances in neurons. Since its introduction more than
ten years ago [13], the dynamic clamp has become a


Source: Abbott, Laurence - Center for Neurobiology and Behavior & Department of Physiology and Cellular Biophysics, Columbia University


Collections: Biology and Medicine