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The importance of being divisible by three in alternative splicing

Summary: The importance of being divisible by three
in alternative splicing
Alon Magen and Gil Ast*
Department of Human Genetics and Molecular Medicine, Sackler Faculty of Medicine,
Tel Aviv University, Ramat Aviv 69978, Israel
Received May 22, 2005; Revised August 10, 2005; Accepted September 7, 2005
Alternative splicing events that are conserved in
orthologous genes in different species are commonly
viewed as reliable evidence of authentic, functionally
significant alternative splicing events. Several
recent bioinformatic analyses have shown that con-
served alternative exons possess several features
that distinguish them from alternative exons that
are species-specific. One of the most striking differ-
ences between conserved and species-specific
alternative exons is the high percentage of exons
that preserve the reading frame (exons whose
length is an exact multiple of 3, termed symmetrical
exons) among the conserved alternative exons.


Source: Ast, Gil - Department of Molecular Genetics and Biochemistry, Tel Aviv University


Collections: Biology and Medicine