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Summary: Journal of Neuroscience Methods 160 (2007) 122127
A floating metal microelectrode array for chronic implantation
Sam Musallama,, Martin J. Bakb,1, Philip R. Troykc,2, Richard A. Andersena,3
a California Institute of Technology, Division of Biology, MC 216-76 Pasadena, CA 91125, United States
b Micro Probe, Inc., 615 Frederick Ave South, Suite 307, Gaithersburg, MD 20877, United States
c Pritzker Institute of Biomedical Science and Engineering, Illinois Institute of Technology, E1-116, Chicago, IL 60616, United States
Received 3 May 2006; received in revised form 25 August 2006; accepted 1 September 2006
Abstract
Implantation of multi-electrode arrays is becoming increasingly more prevalent within the neuroscience research community and has become
important for clinical applications. Many of these studies have been directed towards the development of sensory and motor prosthesis. Here, we
presentamulti-electrodesystemmadefrombiocompatiblematerialthatiselectricallyandmechanicallystable,andemploysdesignfeaturesallowing
flexibility in the geometric layout and length of the individual electrodes within the array. We also employ recent advances in laser machining of thin
ceramic substrates, application of ultra-fine line gold conductors to ceramic, fabrication of extremely flexible cables, and fine wire management
techniques associated with juxtaposing metal microelectrodes within a few hundred microns of each other in the development of a floating
multi-electrode array (FMA). We implanted the FMA in rats and show that the FMA is capable of recording both spikes and local field potentials.
© 2006 Elsevier B.V. All rights reserved.
Keywords: Multi-electrode arrays; Neural prosthesis; Brainmachine interface; Rats
1. Introduction
For over 40 years, metal microelectrodes have been used
to record and stimulate neural tissue (Green, 1958; Mortimer
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