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SUPPLEMENTARY NOTES Monotonicity, frustration, and ordered response: an analysis of
 

Summary: SUPPLEMENTARY NOTES
for
Monotonicity, frustration, and ordered response: an analysis of
the energy landscape of perturbed large-scale biological networks
G. Iacono and C. Altafini
SISSA Int. School for Advanced Studies
via Beirut 2-4, 34014 Trieste, Italy
August 31, 2009
Contents
1 Description of the 8 large-scale networks used in this study 2
2 Model formulation: the signed adjacency matrix of a dynamical system 2
3 Representing transcriptional, signaling and metabolic networks as signed
graphs 3
4 Description of the algorithms for the computation of the frustration index 5
5 Statistical tests 7
6 Analytic computation of internal energy and magnetization: the feedforward
loop example 8
List of Figures
S1 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11
S2 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12

  

Source: Altafini, Claudio - Functional Analysis Sector, Scuola Internazionale Superiore di Studi Avanzati (SISSA)

 

Collections: Engineering; Mathematics