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Multicomponent Reactions DOI: 10.1002/anie.201103567
 

Summary: Multicomponent Reactions
DOI: 10.1002/anie.201103567
A Bioinspired Ugi/Michael/Aza-Michael Cascade Reaction in
Aqueous Media: Natural-Product-like Molecular Diversity**
Soumava Santra and Peter R. Andreana*
The rapid construction of diverse and complex molecular
architectures requires a milieu of chemical knowledge poised
for undertaking synthetic challenges.[13]
As an example,
biologically relevant spirocyclic frameworks possessing qua-
ternary carbon centers that assemble in a regio- and
stereospecific manner from simple substrates have seen
substantial advancements over the years.[4]
In this light,
multicomponent reactions (MCRs) that concomitantly
involve cascade processes have emerged as powerful strat-
egies for assembling higher-ordered structures.[5]
These reac-
tions can sequentially generate multiple stereocenters in a
single transformation,[6]

  

Source: Andreana, Peter R. - Department of Chemistry, Wayne State University

 

Collections: Chemistry