Summary: Multicomponent Reactions
A Bioinspired Ugi/Michael/Aza-Michael Cascade Reaction in
Aqueous Media: Natural-Product-like Molecular Diversity**
Soumava Santra and Peter R. Andreana*
The rapid construction of diverse and complex molecular
architectures requires a milieu of chemical knowledge poised
for undertaking synthetic challenges.
As an example,
biologically relevant spirocyclic frameworks possessing qua-
ternary carbon centers that assemble in a regio- and
stereospecific manner from simple substrates have seen
substantial advancements over the years.
In this light,
multicomponent reactions (MCRs) that concomitantly
involve cascade processes have emerged as powerful strat-
egies for assembling higher-ordered structures.
tions can sequentially generate multiple stereocenters in a