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Sodium Renal Imaging in Mice at High Magnetic Fields Thomas Neuberger,1,2 Vikas Gulani,1,3,4 and Andrew Webb1,2*
 

Summary: Sodium Renal Imaging in Mice at High Magnetic Fields
Thomas Neuberger,1,2 Vikas Gulani,1,3,4 and Andrew Webb1,2*
This work presents the first sodium MRI functional renal study
on a mouse model. The tissue sodium concentration was mon-
itored during induced diuresis with furosemide. By using den-
sity-weighted chemical shift imaging (DWCSI) at high field
strength a temporal resolution of less than 5 min for three
dimensional (3D) data sets with high spatial resolution was
achieved. A maximum increase of 20% in the cortex and a
decrease of 45% of the original signal strength in the medulla
were observed. These findings correspond well with experi-
ments conducted on much larger rodent models. Magn Reson
Med 58:10671071, 2007. 2007 Wiley-Liss, Inc.
Key words: renal imaging; sodium MRI; diuresis; nonuniform
sampling; chemical shift imaging
Since the first studies performed in the early 1980s (1)
renal MRI has become an increasingly useful tool for clin-
ical diagnosis. Today, it allows for a comprehensive exam-
ination of almost the complete spectrum of urologic dis-
eases (2). Functional parameters such as glomerular filtra-

  

Source: Andrews, Anne M. - Huck Institutes of the Life Sciences, Pennsylvania State University

 

Collections: Biology and Medicine