Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
2006 The Society for the Study of Evolution. All rights reserved. Evolution, 60(1), 2006, pp. 1323
 

Summary: 13
2006 The Society for the Study of Evolution. All rights reserved.
Evolution, 60(1), 2006, pp. 13­23
VACCINATION, WITHIN-HOST DYNAMICS, AND VIRULENCE EVOLUTION
JEAN-BAPTISTE ANDRE´ 1,2,3* AND SYLVAIN GANDON4,5*
1Ge´nome, Populations, Interactions, Adaptations, UM2-IFREMER-CNRS UMR 5171, Universite´ des Sciences et Techniques du
Languedoc, CC 105, Ba^timent 24, Place Euge`ne Bataillon 34095 Montpellier Cedex 5, France
2Instituto Gulbenkian de Cie^ncia, Rua da Quinta Grande 6, P-2780-156, Oeiras, Portugal
3E-mail: jeanbaptisteandre@gmail.com
4Ge´ne´tique et Evolution des Maladies Infectieuses, UMR CNRS-IRD 272, IRD, 911 avenue Agropolis,
34394 Montpellier Cedex 5, France
5E-mail: gandon@mpl.ird.fr
Abstract. We explore the potential consequences of vaccination on parasite epidemiology and evolution. Our model
combines a microscopic (within-host dynamics) and a macroscopic (epidemiological dynamics) description of the
interaction between the parasite and its host. This approach allows relevant epidemiological traits such as parasite
transmission, parasite virulence, and host recovery to emerge from a mechanistic model of acute infection describing
the interaction between the parasite and the host immune system. We model the effect of a vaccine as an activator
of immunity enhancing the replication rate of lymphocytes, their initial density at infection's initiation, their efficacy
to kill the parasite, or their activation delay after infection. We analyze the evolution of the replication rate of parasites
and show that vaccination may promote the evolution of faster replicating and, consequently, more virulent strains.

  

Source: André, Jean-Baptiste - CNRS & Université Pierre-et-Marie-Curie, Paris 6
Gregoire, Arnaud - Centre d’Ecologie Fonctionnelle et Evolutive

 

Collections: Biology and Medicine