Summary: TheJournalofExperimentalMedicine
ARTICLE
JEM © The Rockefeller University Press $30.00
Vol. 205, No. 1, January 21, 2008 105-115 www.jem.org/cgi/doi/
105
10.1084/jem.20071367
Protective immunity to tuberculosis depends
on CD4+ T lymphocytes in humans and in mice
(1, 2), but adaptive immune responses are un-
able to eradicate Mycobacterium tuberculosis or to
provide sterile immunity. One characteristic of
the adaptive immune response to tuberculosis is
the long interval required for its development
compared with the response to immunization
or to other infections. In humans, development
of adaptive immunity to tuberculosis, which is
measured as a response to a tuberculin skin test,
requires up to 5­6 wk after infection (3, 4),
whereas in mice, the earliest antigen-specific
CD4+ T cell responses require a minimum of

Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia

Collections: Biotechnology