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Copyright 2011 by the Genetics Society of America DOI: 10.1534/genetics.110.124560
 

Summary: Copyright 2011 by the Genetics Society of America
DOI: 10.1534/genetics.110.124560
Inferences About the Distribution of Dominance Drawn
From Yeast Gene Knockout Data
Aneil F. Agrawal*,1
and Michael C. Whitlock
*Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3B2, Canada and

Department of Zoology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
Manuscript received October 25, 2010
Accepted for publication November 10, 2010
ABSTRACT
Data from several thousand knockout mutations in yeast (Saccharomyces cerevisiae) were used to estimate
the distribution of dominance coefficients. We propose a new unbiased likelihood approach to measuring
dominance coefficients. On average, deleterious mutations are partially recessive, with a mean dominance
coefficient $0.2. Alleles with large homozygous effects are more likely to be more recessive than are alleles
of weaker effect. Our approach allows us to quantify, for the first time, the substantial variance and skew in
the distribution of dominance coefficients. This heterogeneity is so great that many population genetic
processes analyses based on the mean dominance coefficient alone will be in substantial error. These
results are applied to the debate about various mechanisms for the evolution of dominance, and we

  

Source: Agrawal, Aneil F. - Department of Ecology and Evolutionary Biology, University of Toronto

 

Collections: Environmental Sciences and Ecology