| | |
Summary: Current Genomics, 2005, 6, 000-000 1
1389-2029/05 $50.00+.00 ©2005 Bentham Science Publishers Ltd.
Molecular Mechanisms Regulating mRNA Stability: Physiological and
Pathological Significance
Anna M. Knapinska1,2
, Patricia Irizarry-Barreto1
, Sri Adusumalli1
, Ioannis Androulakis3
, and
Gary Brewer1,2,*
1
Department of Molecular Genetics, Microbiology & Immunology, UMDNJ-Robert Wood Johnson Medical School, 675
Hoes Lane, Piscataway, New Jersey 08854 USA; 2
Rutgers University/UMDNJ Joint Graduate Program in Molecular
Pharmacology and 3
Department of Biomedical Engineering, 617 Bowser Rd., Rutgers University, Piscataway, New Jer-
sey 08854 USA
Abstract: The cytoplasmic level of a messenger RNA, and hence protein, depends not only upon its rates of synthesis,
processing, and transport, but its decay rate as well. mRNA decay rates are frequently not static, but vary in response to
extracellular stimuli and viral infections. Sequence elements within an mRNA, together with the protein and/or small non-
|
