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Plasmodium Strain Determines Dendritic Cell Function Essential for Survival from Malaria

Summary: Plasmodium Strain Determines Dendritic Cell
Function Essential for Survival from Malaria
Michelle N. Wykes1
, Xue Q. Liu1
, Lynette Beattie1,2
, Danielle I. Stanisic1,3
, Katryn J. Stacey4
, Mark J. Smyth5
Ranjeny Thomas6
, Michael F. Good1*
1 The Queensland Institute of Medical Research, Brisbane, Queensland, Australia, 2 Immunology and Infection Unit, University of York, York, United Kingdom, 3 Infection and
Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, 4 Institute for Molecular Bioscience, CRC for Chronic Inflammatory
Diseases, University of Queensland, Brisbane, Queensland, Australia, 5 Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia,
6 Centre for Immunology and Cancer Research, University of Queensland, Woolloongabba, Queensland, Australia
The severity of malaria can range from asymptomatic to lethal infections involving severe anaemia and cerebral
disease. However, the molecular and cellular factors responsible for these differences in disease severity are poorly
understood. Identifying the factors that mediate virulence will contribute to developing antiparasitic immune
responses. Since immunity is initiated by dendritic cells (DCs), we compared their phenotype and function following
infection with either a nonlethal or lethal strain of the rodent parasite, Plasmodium yoelii, to identify their contribution


Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia


Collections: Biotechnology