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Leading Edge Slicing across Kingdoms

Summary: Leading Edge
Slicing across Kingdoms:
Regeneration in Plants and Animals
Kenneth D. Birnbaum1,* and Alejandro Sa´ nchez Alvarado2,*
1Department of Biology, Center for Genomics and Systems Biology, New York University, New York, NY 10003, USA
2Howard Hughes Medical Institute, University of Utah School of Medicine Department of Neurobiology and Anatomy,
Salt Lake City, UT 84132, USA
*Correspondence: ken.birnbaum@nyu.edu (K.D.B.), sanchez@neuro.utah.edu (A.S.A.)
DOI 10.1016/j.cell.2008.01.040
Multicellular organisms possessing relatively long life spans are subjected to diverse, constant, and
often intense intrinsic and extrinsic challenges to their survival. Animal and plant tissues wear out as
part of normal physiological functions and can be lost to predators, disease, and injury. Both king-
doms survive this wide variety of insults by strategies that include the maintenance of adult stem
cells or the induction of stem cell potential in differentiated cells. Repatterning mechanisms often
deploy embryonic genes, but the question remains in both plants and animals whether regeneration
invokes embryogenesis, generic patterning mechanisms, or unique circuitry comprised of well-
established patterning genes.
Developmental studies in plants and animals can be thought of


Source: Alvarado, Alejandro Sánchez - Department of Neurobiology and Anatomy, University of Utah


Collections: Biology and Medicine