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Does Litomosoides sigmodontis synthesize dimethylethanolamine from choline?
 

Summary: Does Litomosoides sigmodontis synthesize
dimethylethanolamine from choline?
K. M. HOUSTON1
, S. A. BABAYAN2
, J. E. ALLEN2
and W. HARNETT1
*
1
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street,
Glasgow G4 0NR, UK
2
Institute of Evolution, Immunology and Infection Research, School of Biological Sciences, University of Edinburgh,
West Mains Road, Edinburgh EH9 3JT, UK
(Received 11 June 2007; revised 24 July 2007; accepted 24 July 2007; first published online 25 September 2007)
SUMMARY
Juvenile female Litomosoides sigmodontis secrete a protein (Juv-p120) highly modified with dimethylethanolamine
(DMAE). In an attempt to establish the source of this decoration worms were pulsed with [3
H]-choline and [3
H]-
ethanolamine and the radio-isotope labelled products analysed. Both isotope labels were successfully taken up by the

  

Source: Allen, Judith - School of Biological Sciences, University of Edinburgh
MacDonald, Andrew - Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh

 

Collections: Biology and Medicine