Summary: Structural basis of phosphodiesterase 6 inhibition
by the C-terminal region of the c-subunit
Brandy Barren1
, Lokesh Gakhar2
,
Hakim Muradov1
, Kimberly K Boyd1
,
S Ramaswamy1,2,3
and Nikolai O Artemyev1,
*
1
Department of Molecular Physiology and Biophysics, University
of Iowa, Iowa City, IA, USA and 2
Department of Biochemistry,
University of Iowa, Iowa City, IA, USA
The inhibitory interaction of phosphodiesterase-6 (PDE6)
with its c-subunit (Pc) is pivotal in vertebrate phototrans-
duction. Here, crystal structures of a chimaeric PDE5/
PDE6 catalytic domain (PDE5/6cd) complexed with silde-

Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago

Collections: Biology and Medicine