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Why highly expressed proteins evolve slowly D. Allan Drummond*
 

Summary: Why highly expressed proteins evolve slowly
D. Allan Drummond*
, Jesse D. Bloom
, Christoph Adami*§
, Claus O. Wilke*§
, and Frances H. Arnold
*Program in Computation and Neural Systems and Division of Chemistry and Chemical Engineering, California Institute of Technology,
Pasadena, CA 91125-4100; and §Keck Graduate Institute, Claremont, CA 91711
Edited by Francisco J. Ayala, University of California, Irvine, CA, and approved August 11, 2005 (received for review May 16, 2005)
Much recent work has explored molecular and population-genetic
constraints on the rate of protein sequence evolution. The best
predictor of evolutionary rate is expression level, for reasons that
have remained unexplained. Here, we hypothesize that selection
to reduce the burden of protein misfolding will favor protein
sequences with increased robustness to translational missense
errors. Pressure for translational robustness increases with expres-
sion level and constrains sequence evolution. Using several se-
quenced yeast genomes, global expression and protein abundance
data, and sets of paralogs traceable to an ancient whole-genome
duplication in yeast, we rule out several confounding effects and

  

Source: Arnold, Frances H. - Division of Chemistry and Chemical Engineering, California Institute of Technology

 

Collections: Chemistry; Biology and Medicine