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Mammalian myotube dedifferentiation induced by newt regeneration extract

Summary: Mammalian myotube dedifferentiation induced by
newt regeneration extract
Christopher J. McGann*
, Shannon J. Odelberg*
, and Mark T. Keating§¶
*Department of Internal Medicine, Division of Cardiology, University of Utah, Salt Lake City, UT 84112; and §Howard Hughes Medical Institute,
¶Department of Cell Biology, Harvard Medical School, and Department of Cardiology, Children's Hospital, Boston, MA 02115
Edited by Mark T. Groudine, Fred Hutchinson Cancer Research Center, Seattle, WA, and approved September 4, 2001 (received for review June 12, 2001)
Newts are capable of regenerating several anatomical structures
and organs, including their limbs. This remarkable regenerative
capacity is thought to depend on cellular dedifferentiation. Ter-
minally differentiated mammalian cells, by contrast, are normally
incapable of reversing the differentiation process. Several factors
could explain the absence of cellular dedifferentiation in mammals:
(i) inadequate expression of genes that initiate dedifferentiation;
(ii) insufficient intracellular signaling pathways; (iii) irreversible
expression of differentiation factors; and (iv) structural character-
istics that make dedifferentiation impossible. To investigate the
causes underlying the lack of cellular plasticity in mammalian cells,
we examined the effect of an extract derived from newt regener-


Source: Alvarado, Alejandro Sánchez - Department of Neurobiology and Anatomy, University of Utah


Collections: Biology and Medicine