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Copyright 2002 by the Genetics Society of America Testing Models of Selection and Demography in Drosophila simulans
 

Summary: Copyright 2002 by the Genetics Society of America
Testing Models of Selection and Demography in Drosophila simulans
Jeffrey D. Wall,*,1
Peter Andolfatto
and Molly Przeworski,2
*Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138,
Institute of Cell,
Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom and

Department of Statistics, University of Oxford, Oxford OX1 3TG, United Kingdom
Manuscript received December 10, 2001
Accepted for publication June 12, 2002
ABSTRACT
We analyze patterns of nucleotide variability at 15 X-linked loci and 14 autosomal loci from a North
American population of Drosophila simulans. We show that there is significantly more linkage disequilibrium
on the X chromosome than on chromosome arm 3R and much more linkage disequilibrium on both
chromosomes than expected from estimates of recombination rates, mutation rates, and levels of diversity.
To explore what types of evolutionary models might explain this observation, we examine a model of
recurrent, nonoverlapping selective sweeps and a model of a recent drastic bottleneck (e.g., founder event)
in the demographic history of North American populations of D. simulans. The simple sweep model is

  

Source: Andolfatto, Peter - Department of Ecology and Evolutionary Biology, Princeton University

 

Collections: Biology and Medicine