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Summary: DOPAMINERGIC CONTROL OF WORKING MEMORY
AND ITS RELEVANCE TO SCHIZOPHRENIA: A CIRCUIT
DYNAMICS PERSPECTIVE
S. TANAKAa,b
a
Department of Electrical and Electronics Engineering, Sophia Univer-
sity, 7-1 Kioicho, Chiyoda-ku, Tokyo 102-8554, Japan
b
Department of Psychiatry, Columbia University Medical Center, New
York State Psychiatric Institute, 1051 Riverside Drive, Unit 31, New
York, NY 10032, USA
Abstract--This article argues how dopamine controls work-
ing memory and how the dysregulation of the dopaminergic
system is related to schizophrenia. In the dorsolateral pre-
frontal cortex, which is the principal part of the working
memory system, recurrent excitation is subtly balanced with
intracortical inhibition. A potent controller of the dorsolateral
prefrontal cortical circuit is the mesocortical dopaminergic
system. To understand the characteristics of the dopaminer-
gic control of working memory, the stability of the circuit
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