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Nature GeNetics volume 42 | number 2 | february 2010 105 A rt i c l e s

Summary: Nature GeNetics volume 42 | number 2 | february 2010 105
A rt i c l e s
Impaired beta-cell function and insulin resistance are key determinants
of type 2 diabetes (T2D). Hyperglycemia in the fasting state is one of
the criteria that defines T2D1, it can predict definitive clinical end-
points in nondiabetic individuals2,3 and, when corrected in subjects
with T2D, may help prevent microvascular4,5 and long-term macro-
vascular6,7 complications. To date, there are nearly 20 published loci
reproducibly associated with T2D8; most of these are also associated
with decreased insulin secretion9 due to defective beta-cell function
or beta-cell mass.Association studies for diabetes-related quantitative
traits in participants without diabetes have also identified loci influ-
encing fasting glucose levels, whose effects appear to be mediated by
impairment of the glucose-sensing machinery in beta cells1017.
We recently formed the Meta-Analyses of Glucose and Insulin-
related traits Consortium (MAGIC) to conduct large-scale meta-
analyses of genome-wide data for continuous diabetes-related traits
in participants without diabetes15. We aimed to identify additional
loci that influence glycemic traits in individuals free of diabetes and
investigate their impact on related metabolic phenotypes. We were


Source: Abecasis, Goncalo - Department of Biostatistics, University of Michigan


Collections: Biology and Medicine; Mathematics