The anteriorposterior axis in Caenorhabditis elegans is
determined by the sperm and leads to the asymmetric localisation
of PAR (partitioning-defective) proteins, which are critical for
polarity. New findings demonstrate that sperm asters play a
critical role and suggest models for how PAR asymmetry is
established. In addition, studies of blastomere fate determination
and heterotrimeric G proteins have started to uncover how initial
polarity may be translated into the asymmetric distribution of
maternal proteins and the control of spindle position.
Wellcome/CRC Institute, Tennis Court Road, Cambridge CB2 1QR, UK
Current Opinion in Genetics & Development 2001, 11:367373
0959-437X/01/$ -- see front matter
© 2001 Elsevier Science Ltd. All rights reserved.
AB anterior blastomere at the two-cell stage