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FUNCTIONAL SIGNIFICANCE OF LONG-TERM POTENTIATION FOR SEQUENCE
 

Summary: FUNCTIONAL SIGNIFICANCE OF LONG-TERM
POTENTIATION FOR SEQUENCE
LEARNING AND PREDICTION
L.F. Abbott and Kenneth I. Blum*
Center for Complex Systems
Brandeis University
Waltham, MA 02254
Abstract
Population coding, where neurons with broad and overlapping ring rate tuning curves
collectively encode information about a stimulus, is a common feature of sensory systems.We
use decoding methods and measured properties of NMDA-mediated LTP induction to study
the impact of long-term potentiation of synapses between the neurons of such a coding array.
We nd that, due to a temporal asymmetry in the induction of NMDA-mediated LTP, ring
patterns in a neuronal array that initially represent the current value of a sensory input will,
after training, provide an experienced-based prediction of that input instead. We compute
how this prediction arisesfromand depends on the training experience. We also show how the
encoded prediction can be used to generate learned motor sequences, such as the movement
of a limb. This involves a novel form of memory recall that is driven by the motor response
so that it automatically generates new information at a rate appropriate for the task being
performed.

  

Source: Abbott, Laurence - Center for Neurobiology and Behavior & Department of Physiology and Cellular Biophysics, Columbia University

 

Collections: Biology and Medicine