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Invariant Distribution of Promoter Activities in Escherichia coli
 

Summary: Invariant Distribution of Promoter Activities in
Escherichia coli
Alon Zaslaver1
*, Shai Kaplan2
, Anat Bren2
, Adrian Jinich3,4
, Avi Mayo2
, Erez Dekel2
, Uri Alon2
, Shalev
Itzkovitz3,4
*
1 Division of Biology, California Institute of Technology, Pasadena, California, United States of America, 2 Department of Molecular Cell Biology, Weizmann Institute of
Science, Rehovot, Israel, 3 Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel, 4 Department of Biological
Chemistry, Weizmann Institute of Science, Rehovot, Israel
Abstract
Cells need to allocate their limited resources to express a wide range of genes. To understand how Escherichia coli partitions
its transcriptional resources between its different promoters, we employ a robotic assay using a comprehensive reporter
strain library for E. coli to measure promoter activity on a genomic scale at high-temporal resolution and accuracy. This
allows continuous tracking of promoter activity as cells change their growth rate from exponential to stationary phase in

  

Source: Alon, Uri - Departments of Molecular Cell Biology & Physics of Complex Systems, Weizmann Institute of Science

 

Collections: Biology and Medicine