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Drug Discovery DOI: 10.1002/anie.200907360

Summary: Angewandte
Drug Discovery
DOI: 10.1002/anie.200907360
Structure-Based Discovery of Natural-Product-like
TNF-a Inhibitors**
Daniel Shiu-Hin Chan, Ho-Man Lee, Fang Yang, Chi-Ming Che,
Catherine C. L. Wong, Ruben Abagyan, Chung-Hang Leung,* and Dik-Lung Ma*
2860 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Angew. Chem. Int. Ed. 2010, 49, 2860 2864
Tumor necrosis factor a (TNF-a) is a multifunctional cyto-
kine that acts as a central biological mediator for critical
immune functions, including inflammation, infection, and
antitumor responses.[1]
Dysregulation of TNF-a has been
implicated in cases of tumorigenesis, diabetes, and especially
in autoinflammatory diseases such as rheumatoid arthritis,
psoriatic arthritis, and Crohns disease.[2]
The synthetic anti-
bodies etanercept, infliximab, and adalimumab, approved for


Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego


Collections: Biology and Medicine