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Cis-Regulatory module network Swathi Ashok Kumar

Summary: Cis-Regulatory module network
Swathi Ashok Kumar
-Hardison Lab
Gene Regulation
Types of regulatory elements
G.A. Maston, S.K. Evans, M.R. Green (2006) Ann. Rev. Genomics & Human Genetics 7:29-59.
Human Gamma Globin gene
Cis regulatory elements
Weyth W Wasserman & Albin Sandelin
Genes Co-expressed in Late Erythroid Maturation
G1E-ER cells: proerythroblast line lacking the transcription factor GATA-1.
Can rescue by expressing an estrogen-responsive form of GATA-1
Rylski et al., Mol Cell Biol. 2003
Conservation of predicted binding sites for
transcription factors
Binding site for GATA-1
Regulatory Potential (RP) to distinguish functional classes
Alignment seq1 G T A C C T A C T A C G C A


Source: Albert, Réka - Departments of Biology & Physics, Pennsylvania State University


Collections: Biology and Medicine