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Summary: For many years, a major focus of neuroscience research
has been to understand the cellular changes that occur
during memory acquisition. In particular, this work
has focused on changes in synaptic activity in the hip
pocampus, and long-term potentiation (LTP) has been
identified as a prime candidate for mediating these
changes1,2
.
Different types of LTP have been observed in differ
ent neural structures, including the hippocampus, cer
ebral cortex, amygdala and cerebellum, and LTP can be
further divided into NMDA (Nmethyldaspartate)
receptor (NMDAR)dependent and independent
LTP. The most widely studied type of LTP is NMDAR
dependent LTP at the synapses between Schaffer col
laterals and commissural neurons in area CA1 of the
adult hippocampus3
, which is commonly used as a
basic experimental synaptic model for learning and
memory in vertebrates. LTP is generally split into
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