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Published: August 01, 2011 r 2011 American Chemical Society 3643 dx.doi.org/10.1021/nl201514a |Nano Lett. 2011, 11, 36433648
 

Summary: Published: August 01, 2011
r 2011 American Chemical Society 3643 dx.doi.org/10.1021/nl201514a |Nano Lett. 2011, 11, 36433648
LETTER
pubs.acs.org/NanoLett
Nanoengineering the Heart: Conductive Scaffolds Enhance Connexin
43 Expression
Jin-Oh You, Marjan Rafat, George J. C. Ye, and Debra T. Auguste*
School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States
bS Supporting Information
Cardiac disease is often associated with abnormalities in ele-
ctrical function that can severely impair cardiac perfor-
mance. In many arrhythmias, slow conduction and unidirectional
conduction block result from insufficient intercellular electrical
coupling at gap junctions.1
We hypothesized that electrically
active scaffolds may be used to improve cardiomyocyte function
by increasing connexin 43 (Cx43) expression.
Scaffolds provide the basic, mechanical platform for engineer-
ing a tissue. Scaffolds with similar chemical and mechanical
properties to native tissue have been engineered to improve cell

  

Source: Auguste, Debra T. - School of Engineering and Applied Sciences, Harvard University

 

Collections: Materials Science; Biology and Medicine