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news & views 136 nature genetics volume 27 february 2001
 

Summary: news & views
136 nature genetics volume 27 february 2001
Modifying with mitochondria
Karen B. Avraham
Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. e-mail: karena@post.tau.ac.il
An elegant set of mouse crosses has been used to identify a mitochondrial variant that interacts with a nuclear locus on chromo-
some 10, Ahl, to modify age-related hearing loss. This discovery sets the stage for the identification of factors that modify expres-
sion levels and variability of human hearing impairments.
Genetic and environmental factors influ-
ence the severity of disease phenotypes.
Indeed, our most difficult challenge in the
post-sequencing era will be to understand
and identify the basis of this variability--so
as to better treat disease. Hearing loss, the
most common form of sensory impair-
ment, is no exception. The intricate struc-
ture and multiple cell types of the inner ear
require a range of proteins with different
functions, including maintenance of struc-
tural integrity, neuronal innervation and

  

Source: Avraham, Karen - Department of Human Genetics and Molecular Medicine, Tel Aviv University

 

Collections: Biology and Medicine