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Cell, Vol. 62, 69-106, July 13, 1990, Copyright 0 1990 by Cell Press Interphase Nuclear Envelope Lamins Form a
 

Summary: Cell, Vol. 62, 69-106, July 13, 1990, Copyright 0 1990 by Cell Press
Interphase Nuclear Envelope Lamins Form a
Discontinuous Network That Interacts with Only a
Fraction of the Chromatin in the Nuclear Periphery
Michael R. Paddy, Andrew S. Belmont,"
Harald Saumweber,t David A. Agard,
and John W. Sedat
Structural Biology Unit
Howard Hughes Medical Institute
and Department of Biochemistry and Biophysics
University of California, San Francisco
San Francisco, California 94143-0554
Summary
Antibodies directed against nuclear envelope lamin
proteins have been used in conjunction with three-
dimensional light and electron microscope methodol-
ogies to determine the spatial organization of lamins
in diploid interphase nuclei and to relate this ofganiza-
tion to the positions of chromatin in the nuclear pe-
riphery. Using Drosophila early embryos, Drosophila

  

Source: Agard, David - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collections: Biotechnology; Biology and Medicine