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The Rockefeller University Press $30.00 J. Exp. Med. Vol. 207 No. 7 1369-1380
 

Summary: Article
The Rockefeller University Press $30.00
J. Exp. Med. Vol. 207 No. 7 1369-1380
www.jem.org/cgi/doi/10.1084/jem.20100285
1369
Immature T cell lymphomas represent a sig
nificant portion of human lymphoid malig
nancies (Ferrando and Look, 2000; Armstrong
and Look, 2005). Approximately 50% of these
tumors harbor recurrent chromosomal translo
cations (Aifantis et al., 2008), which likely arise
through errors in the repair of DNA double
strand breaks (DSBs). In this context, normal
mouse and human thymocyte differentiation
requires V(D)J recombination, a process that in
volves the introduction of DSBs at T cell recep
tor (Tcr) loci by the recombinationactivating
gene (RAG) 1 and 2 endonuclease (Bassing
et al., 2002). If such programmed Tcr DSBs are
repaired incorrectly, they can generate chro

  

Source: Alt,, Frederick - Immune Disease Institute, Harvard University

 

Collections: Biology and Medicine