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Identification of novel antimicrobials using a live-animal infection model

Summary: Identification of novel antimicrobials using
a live-animal infection model
Terence I. Moy*
, Anthony R. Ball
, Zafia Anklesaria
, Gabriele Casadei
, Kim Lewis
, and Frederick M. Ausubel*
*Department of Genetics, Harvard Medical School, Boston, MA 02114; Department of Molecular Biology, Massachusetts General Hospital,
Boston, MA 02114; and Department of Biology, Northeastern University, Boston, MA 02115
Contributed by Frederick M. Ausubel, May 16, 2006
The alarming increase of antibiotic-resistant bacterial pathogens
points to the need for novel therapeutic approaches to combat
infection. To discover novel antimicrobials, we devised a screen to
identify compounds that promoted the survival of the model
laboratory nematode Caenorhabditis elegans infected with the
human opportunistic pathogen Enterococcus faecalis. E. faecalis
colonizes the nematode intestinal tract, forming a persistent lethal
infection. Infected nematodes were rescued by antibiotic treat-
ment in a dose-dependent manner, and antibiotic treatment mark-


Source: Ausubel, Frederick M. - Department of Genetics, Harvard University


Collections: Biology and Medicine