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ParatransgenesisAppliedfor Control of TsetseTransmittedSleepingSickness

Summary: CHAPTER3
ParatransgenesisAppliedfor Control
of TsetseTransmittedSleepingSickness
SerapAksoy,* BrianWeiss and GeoffreyAttardo
frican trypanosomiasis (sleeping sickness) is a major cause of morbidity and mortality
in Subsaharan Africa for human and animal health. In the absence of effectivevaccines
and efficacious drugs, vector control is an alternative intervention tool to break the
diseasecycle.This chapter describes the vectorial and symbiotic biologyof tsetse with emphasis
on the current knowledge on tsetse symbiont genomics and functional biology; and tsetses
trypanosome transmission capability. The ability to culture one of tsetse's commensal symbi-
otic microbes, Sodalisin vitro has allowed for the development of a genetic transformation
system for this organism. Tsetsecan be repopulated with the modified Sodalissymbiont, which
can express foreign gene products (an approach we refer to as paratransgenic expression sys-
tem). Expanding knowledge on tsetse immunity effectors, on genomics of tsetse symbionts
and on tsetses parasite transmission biology stands to enhance the development and potential
application of paratransgenesis as a new vector-control strategy. We describe the hallmarks of
the paratransgenic transformation technology where the modified symbionts expressing try-
panocidal compounds can be used to manipulate host functions and lead to the control of


Source: Aksoy, Serap - School of Public Health, Yale University


Collections: Biology and Medicine