Summary: Current Biology, Vol. 13, 47­52, January 8, 2003, 2003 Elsevier Science Ltd. All rights reserved. PII S0960-9822(02)01396-9
Caenorhabditis elegans Innate Immune Response
Triggered by Salmonella enterica Requires Intact
LPS and Is Mediated by a MAPK Signaling Pathway
known to mediate stress responses and is activated by
heat shock, ultraviolet (UV) light, the proinflammatory
cytokines IL-1 or TNF- , or bacterial LPS [6­8]. One
consequence of p38 activation in mammalian cells is
programmed cell death (PCD). In C. elegans, stress-
Alejandro Aballay,1,2,
* Eliana Drenkard,1
Layla R. Hilbun,2
and Frederick M. Ausubel1
1
Department of Genetics
Harvard Medical School and
Department of Molecular Biology
Massachusetts General Hospital activated PCD occurs in C. elegans gonadal cells, and
a low level of gonadal programmed cell death occursBoston, Massachusetts 02114
2

Source: Ausubel, Frederick M. - Department of Genetics, Harvard University

Collections: Biology and Medicine