Summary: The Genetic Landscape of Type 2 Diabetes in Mice
Susanne M. Clee and Alan D. Attie
Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706-1544
Inbred mouse strains provide genetic diversity comparable to
that of the human population. Like humans, mice have a wide
range of diabetes-related phenotypes. The inbred mouse
strains differ in the response of their critical physiological
functions, such as insulin sensitivity, insulin secretion, -cell
proliferation and survival, and fuel partitioning, to diet and
obesity. Most of the critical genes underlying these differ-
ences have not been identified, although many loci have been
mapped. The dramatic improvements in genomic and bioin-
formatics resources are accelerating the pace of gene discov-
ery. This review describes how mouse genetics can be used to
discover diabetes-related genes, summarizes how the mouse
strains differ in their diabetes-related phenotypes, and de-
scribes several examples of how loci identified in the mouse
may directly relate to human diabetes. (Endocrine Reviews 28:
48­83, 2007)
I. Physiological Definition

Source: Attie, Alan D. - Department of Biochemistry, University of Wisconsin at Madison

Collections: Biology and Medicine