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Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis
 

Summary: Killing of Caenorhabditis elegans by Cryptococcus
neoformans as a model of yeast pathogenesis
Eleftherios Mylonakis*, Frederick M. Ausubel§
, John R. Perfect¶
**, Joseph Heitman **
,
and Stephen B. Calderwood*
*Division of Infectious Diseases and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114; Departments of Genetics and
Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115; and ¶Division of Infectious Diseases, Department of Medicine,
**Department of Molecular Genetics and Microbiology, and Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710
Contributed by Frederick M. Ausubel, September 18, 2002
We found that the well-studied nematode Caenorhabditis elegans
can use various yeasts, including Cryptococcus laurentii and Crypto-
coccus kuetzingii, as a sole source of food, producing similar brood
sizes compared with growth on its usual laboratory food source
Escherichia coli OP50. C. elegans grown on these yeasts had a life span
similar to (C. laurentii) or longer than (C. kuetzingii) those fed on E.
coli.However,thehumanpathogenicyeastCryptococcusneoformans
killed C. elegans, and the C. neoformans polysaccharide capsule as
well as several C. neoformans genes previously shown to be involved

  

Source: Ausubel, Frederick M. - Department of Genetics, Harvard University

 

Collections: Biology and Medicine